• 咨询热线
    客服服务热线 13671568941/15317326293
  • 在线咨询
  • 微信客服
    微信客服
  • 公众号
    扫码关注公众号

GBR 12783 dihydrochloride

CAS No. 67469-75-4

GBR 12783 dihydrochloride ( GBR12783 2HCl )

产品货号. M27078 CAS No. 67469-75-4

GBR 12783 diHClide 可改善大鼠的记忆力并增加海马乙酰胆碱的释放。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
2MG ¥624 有现货
5MG ¥988 有现货
10MG ¥1442 有现货
25MG ¥2406 有现货
50MG ¥3669 有现货
100MG ¥5306 有现货
500MG ¥11016 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    GBR 12783 dihydrochloride
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    GBR 12783 diHClide 可改善大鼠的记忆力并增加海马乙酰胆碱的释放。
  • 产品描述
    GBR 12783 dihydrochloride can improve memory performance and increase hippocampal acetylcholine release in rats.GBR 12783 dihydrochloride is a specific, potent and selective dopamine uptake inhibitor that inhibits the [3H]dopamine uptake by rat and mice striatal synaptosomes with IC50s of 1.8 nM and 1.2 nM, respectively.(In Vivo):GBR 12783 (10 mg/kg;?intraperitoneal injection;?for 100 minutes;?male Sprague-Dawley rats) treatment reinforces specifically dopamine transmission only at synapses instantaneously active, increases hippocampal ACh release and improves memory performance in a passive avoidance task.
  • 体外实验
    ——
  • 体内实验
    GBR 12783 (10 mg/kg; intraperitoneal injection; for 100 minutes; male Sprague-Dawley rats) treatment reinforces specifically dopamine transmission only at synapses instantaneously active, increases hippocampal ACh release and improves memory performance in a passive avoidance task. Animal Model:Male Sprague-Dawley rats (180-200 g) Dosage:10 mg/kg Administration:Intraperitoneal injection; for 100 minutes Result:For a moderate electric shock intensity (0.4 mA), improveed retention performance, increased hippocampal acetylcholine release in vivo.
  • 同义词
    GBR12783 2HCl
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    AMPAR
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    67469-75-4
  • 分子量
    485.49
  • 分子式
    C28H34Cl2N2O
  • 纯度
    >98% (HPLC)
  • 溶解度
    ——
  • SMILES
    Cl.Cl.C(CN1CCN(C\C=C\c2ccccc2)CC1)OC(c1ccccc1)c1ccccc1
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1.Jhee SS, Chappell AS, Zarotsky V, et al. Multiple-dose plasma pharmacokinetic and safety study of LY450108 and LY451395 (AMPA receptor potentiators) and their concentration in cerebrospinal fluid in healthy human subjects. J Clin Pharmacol. 2006 Apr;46(4):424-32.
产品手册
关联产品
  • Dansyl chloride

    丹磺酰氯与脂肪族胺和芳香族胺中的伯氨基反应,生成稳定的蓝色或蓝绿色荧光磺酰胺加合物。它广泛用于修饰氨基酸,特别是蛋白质测序和氨基酸分析。

  • 2-O-Acetyl-20-hydrox...

    2-O-Acetyl-20-Hydroxyecdysone 是昆虫和陆生植物中的一种蜕皮甾酮,可抑制淀粉样蛋白-β42 (Aβ42) 诱导的细胞毒性。

  • AtPep3

    AtPep3 is a hormone-like peptide that plays a role in the salinity stress tolerance of plants.