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GBR 12783 dihydrochloride
CAS No. 67469-75-4
GBR 12783 dihydrochloride ( GBR12783 2HCl )
产品货号. M27078 CAS No. 67469-75-4
GBR 12783 dihydrochloride can improve memory performance and increase hippocampal acetylcholine release in rats.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥624 | 有现货 |
|
| 5MG | ￥988 | 有现货 |
|
| 10MG | ￥1442 | 有现货 |
|
| 25MG | ￥2406 | 有现货 |
|
| 50MG | ￥3669 | 有现货 |
|
| 100MG | ￥5306 | 有现货 |
|
| 500MG | ￥11016 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称GBR 12783 dihydrochloride
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述GBR 12783 dihydrochloride can improve memory performance and increase hippocampal acetylcholine release in rats.
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产品描述GBR 12783 dihydrochloride can improve memory performance and increase hippocampal acetylcholine release in rats.GBR 12783 dihydrochloride is a specific, potent and selective dopamine uptake inhibitor that inhibits the [3H]dopamine uptake by rat and mice striatal synaptosomes with IC50s of 1.8 nM and 1.2 nM, respectively.(In Vivo):GBR 12783 (10 mg/kg;?intraperitoneal injection;?for 100 minutes;?male Sprague-Dawley rats) treatment reinforces specifically dopamine transmission only at synapses instantaneously active, increases hippocampal ACh release and improves memory performance in a passive avoidance task.
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同义词GBR12783 2HCl
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通路Others
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靶点Other Targets
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受体AMPAR
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研究领域——
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适应症——
化学信息
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CAS Number67469-75-4
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分子量485.5
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分子式C28H34Cl2N2O
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纯度>98% (HPLC)
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溶解度——
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SMILESCl.Cl.C(CN1CCN(C\C=C\c2ccccc2)CC1)OC(c1ccccc1)c1ccccc1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Jhee SS, Chappell AS, Zarotsky V, et al. Multiple-dose plasma pharmacokinetic and safety study of LY450108 and LY451395 (AMPA receptor potentiators) and their concentration in cerebrospinal fluid in healthy human subjects. J Clin Pharmacol. 2006 Apr;46(4):424-32.
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